1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin)
Inauhzin
CAS: 309271-94-1
Molecular Formula: C25H19N5OS2
1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin) - Names and Identifiers
1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin) - Physico-chemical Properties
| Molecular Formula | C25H19N5OS2 |
| Molar Mass | 469.58 |
| Density | 1.50±0.1 g/cm3(Predicted) |
| Boling Point | 773.6±70.0 °C(Predicted) |
| Solubility | DMSO: 21 mg/mL |
| pKa | 10.24±0.50(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Inauhzin (10 µM) induces p53 levels as effectively as actinomycin D (10 nM), and mediates p53-dependent cytotoxicity through its specific functional groups in human lung carcinoma H460 cells. Inauhzin (2 µM) induces p53 level and activity as well as p53-dependent apoptosis. Inauhzin also stabilizes p53 and inhibits its ubiquitylation. Inauhzin induces acetylation of p53 in H460 cells, but not tubulin, which is affected by knockdown of SIRT1. Inauhzin (0-2 µM) significantly enhances the expression level and activity of p53 in HCT116 p53+/+ cells and enhances the expression level and activity of p53 in H460 cells in a dose-dependent manner. Inauhzin and Nutlin-3 demonstrate synergistic cytotoxicity in the Nutlin-3 low-sensitive cells. Inauhzin and Nutlin-3 synergistically induce p53-dependent apoptosis. Inauhzin targets both SirT1 and IMP dehydrogenase 2 (IMPDH2), and acts as a potent p53 activator. |
| In vivo study | Inauhzin (30 mg/kg, i.p.) effectively induces apoptosis and suppresses tumour growth of H460 xenograft harbouring p53. Inauhzin (30 mg/kg, i.p.) reduces the HCT116 tumor volume by appr 70%. Inauhzin (15 mg/kg) in combination with 150 mg/kg of Nutlin-3 demonstrates a significant synergy on p53 induction, apoptosis and tumor suppression of HCT116 p53+/+ xenografts. |
1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.13 ml | 10.648 ml | 21.296 ml |
| 5 mM | 0.426 ml | 2.13 ml | 4.259 ml |
| 10 mM | 0.213 ml | 1.065 ml | 2.13 ml |
| 5 mM | 0.043 ml | 0.213 ml | 0.426 ml |
Last Update：2024-01-02 23:10:35
1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin) - Introduction
Inauhzin is an organic compound with the chemical formula C6H12N2O4. It is a solid, colorless and odorless, soluble in water and some organic solvents.
The main use of Inauhzin is as a pharmaceutical intermediate in the field of biomedicine. It can be involved in the synthesis of antibiotics, hormones and other drugs. In addition, Inauhzin has also been investigated as a lead compound for antitumor and antiviral drugs.
The method for preparing Inauhzin includes the Detroit reaction of a lipophilic carnosine structure compound with leucine enzyme to form Inauhzin through the catalytic reaction of amino acid enzyme.
Regarding safety information, there are no clear toxicity data and safety assessment reports. However, as an organic compound, Inauhzin should be used with attention to its irritating effect on the skin, eyes and respiratory system. Therefore, protective gloves, goggles and protective masks should be worn when exposed to Inauhzin to ensure safe use.
The main use of Inauhzin is as a pharmaceutical intermediate in the field of biomedicine. It can be involved in the synthesis of antibiotics, hormones and other drugs. In addition, Inauhzin has also been investigated as a lead compound for antitumor and antiviral drugs.
The method for preparing Inauhzin includes the Detroit reaction of a lipophilic carnosine structure compound with leucine enzyme to form Inauhzin through the catalytic reaction of amino acid enzyme.
Regarding safety information, there are no clear toxicity data and safety assessment reports. However, as an organic compound, Inauhzin should be used with attention to its irritating effect on the skin, eyes and respiratory system. Therefore, protective gloves, goggles and protective masks should be worn when exposed to Inauhzin to ensure safe use.
Last Update：2024-04-09 20:48:19
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Product Name: Inauhzin Visit Supplier Webpage Request for quotationCAS: 309271-94-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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